The Anatomy Lesson of Dr. Tulp

by Rembrandt 1632

Our laboratory performs orthopaedic biomechanics and rehabilitation research of the hand and upper extremity. Currently, our research activities focus on carpal tunnel mechanics and hand sensorimotor function with a clinical focus on carpal tunnel syndrome and hand/wrist arthritis. Our work related to carpal tunnel mechanics involves studying the material and mechanical properties of the transverse carpal ligament (i.e. the volar boundary of the carpal tunnel), investigating the structural properties of the carpal tunnel, and creating a computational model for the tunnel complex. Related to hand sensorimotor function, we have been examining the pathomechanics and pathophysiology associated with carpal tunnel syndrome. We study joint mechanics and pathomechanics as they related to arthritic condition at the trapeziometacarpal and intercarpal joints. Our research involves cutting edge bioengineering using including motion analysis, ultrasound imaging, computer tomography, magnetic resonance imaging, electromyography, electroencephalogram, robotics, and computational modeling.

Selected Publications

    • Yao Y, Grandy EL, Evans PJ, Seitz WH, Li ZM (2018). Enhancement in median nerve mobility during radioulnar wrist compression in carpal tunnel syndrome patients, Clinical Biomechanics 60:83-88
    • Kolmodin J, Davidson IU, Jun BJ, Sodhi N, Subhas N, Patterson TE, Li ZM, Iannotti JP, Ricchetti ET (2018). Scapular notching after reverse total shoulder arthroplasty: prediction using patient-specific osseous anatomy, implant location, and shoulder motion. J Bone Joint Surg Am 100(13):1095-1103. doi: 10.2106/JBJS.17.00242
    • Yao Y, Erdemir A, Li ZM (2018). Finite element analysis for transverse carpal ligament tensile strain and carpal arch area. Journal of Biomechanics 73(17):210-216. NIHMS959237
    • Walia P, Erdemir A, Li ZM (2017). Subject-specific finite element analysis of the carpal tunnel cross-sectional to examine tunnel area changes in response to carpal arch loading. Clinical Biomechanics 42:25-30
    • Marquardt TL, Evans PJ, Seitz WH, Li ZM (2016). Carpal arch and median nerve changes during radioulnar wrist compression in carpal tunnel syndrome patients. Journal of Orthopaedic Research 34(7):1234-40. NIHMSID: NIHMS 747452
    • Gabra JN, Li ZM (2016). Three-dimensional stiffness of the carpal arch. Journal of Biomechanics. 49(1):53-59
    • Li K, Evans PJ, Seitz WH, Li ZM (2015). Carpal tunnel syndrome impairs sustained precision pinch performance, Clinical Neurophysiology 126(1):194-201
    • Nataraj R, Evans PJ, Seitz WH, Li ZM (2014). Pathokinematics of precision pinch movement associated with carpal tunnel syndrome. Journal of Orthopaedic Research 32:786-792
    • Marquardt TL, Nataraj R, Evans PJ, Seitz WH, Li ZM (2014). Carpal tunnel syndrome impairs thumb opposition and circumduction motion. Clinical Orthopaedics and Related Research 472(8):2526-2533
    • Shen ZL, Li ZM (2013). Biomechanical interaction between the transverse carpal ligament and the thenar muscles. Journal of Applied Physiology 114: 225–229
    • Kim DH, Marquardt TL, Gabra JN, Shen ZL, Evans PJ, Seitz WH, Li ZM (2013). Pressure-morphology relationship of a released carpal tunnel. Journal of Orthopeadic Research. 31(4):616-620
    • Li ZM, Latash ML, Zatsiorsky VM (1998) Force sharing among fingers as a model of the redundancy problem. Experimental Brain Research 119(3):276-286